Anxiety and insomnia are biological barriers that affect one eighth of world population. The pharmacotherapy for managing these modern transmitted diseases includes psychotropic drugs, including barbiturate, benzodiazepines, azospirone, norepinephrine and serotonin reuptake inhibitors, monoamine oxidase inhibitor and phenotheiazine. Among them, benzodiazepines are the most widely used recipe of Synthetic drugs, which is used to treat anxiety, insomnia, epilepsy and stress disorder. Frequently used benzodiazepines will lead to Cognitive deterioration, addiction, physical dependence and toleration. Because of side effect related to synthetic drugs, present researchers are exploring natural resources to find more safe and effective drugs.
Apigenin is also called apiolin, and it's a kind of flavonoid, widely scattered in the nature. It mainly exists in thymelaeceae, verbenaceae and plants of the selaginae family, widely scattered in vegetables and fruits of the temperature and tropical region, especially high content in celery. Large studies show that apigenin has many biological activities including anti-tumor, cardio-cerebrovascular protection, antiviral, anti-bacteria, etc. Apigenin can restrain carcinogenic activity of cancerogenic substance; can be antiviral drug for treating HIV and other virus infections; can be inhibitor of MAP kinase; can treat various inflammations; be antioxidant; be sedation and dialectic treatment, and therapeutic action of apigenin anxiety; decompression. Then do you know how to conduct treatment of apigenin anxiety?
New lab studies show that flavonoid apigenin is a kind of matter existing in parsley, thyme, chamomile and pimiento. It can improve neurogenesis and reinforce connections between brain cells, etc. Except for apigenin anxiety treatment, it also has the potential of treating schizophrenia, depression, Alzheimer's disease, Parkinson's disease, etc. Previous animal experiment has shown that it and apigenin belong to same chemical group matter, etc. It has active influence on memory and study. Except for apigenin anxiety treatment, many studies emphasize that flavonoidhas potential of protecting and increasing brain function.
Although flavonoid's effectiveness on brain health is not a brand-new concept, the study first shows that apigenin has active impact directly on human cells, and first reveals its mechanism. For apigenin anxiety, fractionation guided by bioacitivity is used. For apigenin anxiety, antianxiety activity of plant methanol extracts guide fractionation and leads to separation of 5,7,4'-trihydroxyflavone apigenin. Its structure is stated by UV and NMR data. For mouses of elevated plus maze anxiety model, apigenin shows obvious antianxiety activity under oral dose of 2 mg/kg.