Isoquercitrin CAS NO.482-35-9

What Are Side Effects of Isoquercitrin?

The common side effects of oral isoquercitrin are numbness in arms and legs; headache. Very high doses of intravenous isoquercitrin may cause certain side effects in some people, such as flushing and sweating, nausea and vomiting, difficulty breathing, kidney damage, etc.

Another possible side effect associated with excessive intake of isoquercitrin is that it may interfere with thyroid function. In addition to side effects such as thyroid dysfunction, taking isoquercitrin may also worsen the condition of patients with kidney disease.

Excessive intake of isoquercitrin may cause many side effects, including interference with normal thyroid function. Avoid taking quercetin supplements without the guidance of your healthcare practitioner to avoid side effects.

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Isoquercitrin VS Quercetin: What's the Difference?

First of all, quercetin and isoquercitrin, both are natural plant flavonoids. Quercetin itself has two molecules of bound water (dihydrate), the molecular formula is C15H10O7+2H2O, so quercetin dihydrate Quercetin is a more stringent name for quercetin raw materials, but in the determination of quercetin content, the content of anhydrous quercetin must be calculated, which means that two molecules of water must be removed from the calculation. From the perspective of the chemical structure, dihydroquercetin is the reduced form of quercetin, which is the product of hydrogenating the double bond at positions 2 and 3 in the flavonoid core, with the molecular formula C15H12O7, while isoquercitrin is a glycoside. Quercetin is an aglycone, which is commonly known as a glycoside. isoquercitrin is a skeleton with a glucose added with a molecular formula of C21H20O12. Quercetin and isoquercitrin are both derived from rutin for desugar treatment. The removal of one sugar (rhamnose) forms isoquercitrin, and the removal of two sugars (glucose + rhamnose) forms quercetin. In terms of water solubility, quercetin is insoluble in water and can only be made into tablets, while dihydroquercetin and isoquercitrin have better water solubility. In terms of bioavailability, isoquercitrin has been proven to have a higher bioavailability and faster absorption rate than quercetin or quercetin (rutin), and its rate is about twice that of quercetin. It is ten times higher than quercetin (rutin). The glucose part of isoquercitrin accelerates the uptake of molecules and the conversion to quercetin.

Technical Data Sheet (TDS) of Isoquercitrin Powder