Chengdu Kindarco Biotech Co, Ltd.
Chengdu Kindarco Biotech Co, Ltd.
  • Hesperetin Structure
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  • Hesperetin Structure
  • hesperetin

Hesperetin CAS No.520-33-2

Product nameHesperetin
Herbal SourceCitrus Aurantium L.
CAS NO520-33-2
Hesperetin Chemical FormulaC16H14O6
Hesperetin Molecular Weight302.27
Test MethodHPLC
AppearanceLight yellow to off-white powder
Hesperetin SolubilityEasily soluble in ethanol, soluble in diluted alkali solution, partly soluble in diethyl ether, slightly soluble in water, chloroform and benzene.
Hesperetin Food SourcesCitrus Fruits and Juices.

Hesperetin is a kind of natural flavonoid compound, widely existing in the fruits of rutaceous plants. Hesperidin and hesperetin have a close relationship with each other. Hesperetin mainly comes from decomposed enzymatically hesperidin with the appearance of light yellow or off-white powder. Hesperetin structure is very complex with the three hydroxy groups located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position. Hesperetin is widely used in the food, nutraceutical and cosmetics industries.

Hesperetin was listed in FEMA as the raw material of flavours and fragrances in 2007 with FEMA No. 4313 and also listed in SFDA GB2760 in 2017 with No.N375.

As a plant extract supplier, Chengdu Kindarco Biotech provides various kinds of hesperetin products with high quality. If you want to buy hesperetin products or other Citrus Aurantium Extract like apigenin 520 36 5 ,  naringenin powder etc, please contact us!

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Benefits of Hesperetin for Health

Hesperetin has a wide range of pharmacological effects. Hesperetin will not accumulate in any organs, it is safe to use and has no obvious side effects. Early research on the pharmacological effects of hesperetin mainly focused on anti-bacterial, anti-inflammatory, anti-oxidant, anti-viral, anti-allergic, regulation of blood lipids, enhancement of immunity and anti-cancer.

  • Benefits of Hesperetin for Food and Flavors
    Benefits of Hesperetin for Food and Flavors

    1. Hesperetin can enhance the sweet taste of sweet-tasting substances, and reduce the amount of sucrose used.

    2. Hesperetin can improve the unpleasant taste of food, and increase the degree of deliciousness.

    3. Hesperetin can enhance the sweet olfactory impression of sweeteners.

  • Benefits of Hesperetin Supplement as Nutraceuticals
    Benefits of Hesperetin Supplement as Nutraceuticals

    1. Hesperetin is a kind of antioxidant plant extract. And hesperetin supplement has the remarkable function of anti-inflammation and antioxidant.

    2. Hesperetin supplement has significant regulation and inhibition function of cardiovascular protection and reducing blood lipid.

    3. Hesperetin can reduce toxicity damage of nervous excitability and play a role in protecting the nervous system.

  • Benefits of Hesperetin Used in Cosmetics
    Benefits of Hesperetin Used in Cosmetics

    1. Protect skin from environmental damages and prevent tanning and sunburn.

    2. Improve microcirculation, and eliminate the related symptoms of microcirculation (such as dark circles).

    3. Prevent skin ageing symptoms, improve skin dullness, and make the skin become smooth and flexible.

    4. Control the formation of sebum, and prevent skin acne;

    5. Hesperetin can be esterified with lauric acid to obtain hesperetin laurate, which is widely used in cosmetics.

What is Hesperetin Used For?

Hesperetin is one type of citrus aurantium fructus extracts and often used in food, medicine, health-care products and cosmetics. Hesperetin and its derivatives can be used in the treatment of Alzheimer's disease, Parkinson's disease, hyperglycemia, venom hemagglutinin, anti-lung, kidney, and liver fibrosis, and inhibit some new tumors. For example, Parkinson’s disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic nerve cells in the brain. Hesperetin has a positive effect on cell apoptosis, inflammation and oxidative stress. In addition, hesperetin has an anti-snake venom hemagglutinin effect, is a non-competitive SVSP1 and SVSP2 inhibitor, and can be used as a low-cost inhibitor for the study of snake venom protease. If you want to know more, please contact us.

Hesperidin and Hesperetin: What's the Difference?

Hesperetin and Hesperidin are different substances. Hesperetin is a chemical substance with a molecular formula of C16H14O6. It is mainly derived from young fruits of the citrus genus of the Rutaceae family, which belongs to one of the dihydroflavonoids. It is light yellow needle-like crystal or powder. Hesperidin is also known as Chuanpisu; Dihydroflavonoid glycosides, molecular formula C28H34O15, are white or light yellow crystalline powder; odorless and tasteless. It is easily soluble in pyridine or dimethylformamide, but insoluble in ethanol or water. But the functions of the two are similar. Both have the functions of anti-oxidation and elimination of free radicals, regulating the cardiovascular system, and can protect the nervous system, anti-allergic and dermatitis, anti-bacteria and microorganisms, anti-cancer and genotoxicity.

Technical Data Sheet (TDS) of Hesperetin Powder

Assay Item


Test Result

Assay( on dry Product)




≥90.0% (HPLC)
≥95.0% (HPLC)

≥98.0% (HPLC)


Light yellow to off-white powder



None to slight


Heavy metals


















Sulfated ashes



Solvent residue



Particle size

95% Through 80 mesh





Mould and Yeast






Escherichia coli



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