Phloretin Can Improve Vascular Endothelial Dysfunction and Disorders

Phloretin belongs to the plant polyphenols of dihydrochalcone, which can be extracted from apple and grapefruit peels and can play a role in protecting plants from UV damage. Phloretin can be directly absorbed by the human body, but in plants, there are very few naturally occurring phloretin, and most of phloretin exists in the form of its glycoside derivative, that is, phloretin, which is absorbed by the human body in the gastric mucosa. Only after the glycosides are removed to form phloretin, it can enter the circulatory system and exert its effect.

1. Phloretin has antitumor activity

The study found that phloretin induces tumor cell apoptosis by inhibiting the transport of glucose in tumor cells. Studies have found that phloretin can inhibit the proliferation of cancer cells and induce their apoptosis in a concentration- and time-dependent manner. Phloretin powder can block the cell cycle in the G1 phase. Calcium balance to induce cancer cell apoptosis.

2. Phloretin can improve vascular endothelial dysfunction and disorders

The phloretin group and the higher choline group can significantly reduce the serum levels of total cholesterol, triacylglycerol, alanine aminotransferase, aspartate aminotransferase, endothelin-1 and thromboxane A2, and significantly antagonize the levels of prostacyclin and NO in serum. level, improve vascular endothelial function. In addition, phloretin can enhance the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPX) in the liver, and reduce the level of malondialdehyde. protective effect. Other studies have shown that phloretin can act on ion channels in cells, inhibit calcium influx through potential-dependent calcium channels or inhibit phosphoinositide 3-induced calcium release from the endoplasmic reticulum, thereby affecting the aorta. contraction and protect blood vessels. Many plant based extracts have great benefits to people's health.

3. Phloretin has the effect of promoting membrane absorption

Phloretin is a lipophilic compound, and phloretin has a certain effect on the cell membrane, which can affect the carrier-mediated transport process. Studies have shown that purified plant extracts phloretin can inhibit the activity of melanocytes, has a lightening effect on various skin pigmentation, and has a good inhibitory effect on tyrosinase. It is a very safe and effective freckle whitening agent. In vitro tyrosinase Activity experiments showed that phloretin inhibited tyrosinase activity in a competitive and dose-dependent manner.