Efficacy and Function of Naringenin

1. What is naringenin

With the color of white or canary yellow, naringenin is a kind of odorless flavanone which is a kind of flavonoid. It not only is the main flavanone in grapefruit, but also is found in many fruits and herbs. Naringenin has the skeleton structure of flavanone, in which there are three OH groups at the carbon atoms at positions 4', 5 and 7. Naringenin can be monomeric or exist as glycosides, that is, naringin that consists of added disaccharide new orange peel sugar and the carbon atoms at position 7. Like most flavanone, naringenin has a chiral center at carbon 2, though the optical purity is variable. The racemate of S (-) -naringenin has been shown to occur quite rapidly.

2. Efficacy and function of naringenin

There are several naringenin benefits. Let KINDARCO introduce to you.

(1) Antibacterial, antifungal and antiviral. Naringenin has antibacterial effect on staphylococcus epidermidis, staphylococcus aureus, bacillus subtilis, staphylococcus flavus and bacterium coli. Then the further researches proved the antibacterial effect on lactococcus lactis, lactobacillus acidophilus, actinomyces naeslundii, oral prevotella acidophilus, propionibacterium melanin, porphyromonas gingivalis, candida albicans, candida tropicalis and klebsiella and others. Though it's not proved that naringin has inhibitory effect on urease activity of microorganism, there is evidence that it has antibacterial effect on Helicobacter pylori.

Naringenin can inhibit the production of HCV infected hepatocyte virus cultured in vitro, which may be secondary to the inhibitory effect of naringenin on the secretion of very low density lipoprotein. Besides, the antiviral effect of naringin is under clinical research currently. Reports about antiviral effect of poliovirus HSV-1 and HSV-2 have been published though the replication of the virus was not inhibited.

(2) Antioxidant. Naringenin has been shown to have significant antioxidant properties. It's proved in both vitro and animal in vivo studies that it can reduce oxidative damage to DNA.

(3) Anti-tumor. According to reports, naringenin can induce cytotoxicity in leukemia cells as well as cancer cells of breast cancer, gastric cancer, liver cancer, cervical cancer, pancreatic cancer and colon cancer. The mechanism of naringenin inhibiting the growth of human breast cancer has been confirmed. Based on this, two anticancer hypotheses of naringenin are proposed. One hypothesis is that naringenin inhibits aromatase, thereby inhibiting the growth of tumor. Another hypothesis suggests that the interaction between naringenin and estrogen receptor is the reason why it can regulate the growth of tumor. The new derivatives of naringin have activity against multidrug resistant cancer.