Chengdu Kindarco Biotech Co, Ltd.
Chengdu Kindarco Biotech Co, Ltd.

Apigenin and Cancer Chemoprevention

Cancer prevalence patterns occur within regions as populations age or gradually urbanize. Since changes in dietary habits can affect cancer rates, immigration also contributes to this change. These epidemiological findings strongly suggest that cancer incidence is largely preventable by environmental factors, including diet.


Cancer can be largely prevented through diet by increasing your intake of fruits and vegetables. Can be treated with apigenin to fight cancer. Apigenin is a naturally occurring plant flavonoid (4', 5, 7,-trihydroxyflavonoid) found in large amounts in common fruits and vegetables, including parsley, onions, oranges, tea, chamomile, wheat sprouts and some seasoning. Apigenin anticancer therapy has been shown to have significant anti-inflammatory, antioxidant and anticancer properties. In the past few years, significant progress has been made in studying the biological effects of apigenin at the cellular and molecular levels. Appropriate amount of apigenin anticancer dose has chemopreventive effect, and it has great development potential as a chemopreventive agent for apigenin anticancer therapy.


1. Apigenin breast cancer: from chemistry to medicine


Breast cancer is one of the most common causes of death in women worldwide. Metabolic disorders, alcohol consumption, hormone replacement therapy, genetic predisposition, and infertility are well-known risk factors for breast cancer. Surgery, radiation, and chemotherapy are limited treatment options for breast cancer. Therefore, there is a growing need to find new chemopreventive agents that may be effective in preventing and/or managing breast cancer. Natural products such as flavonoids provide a variety of anticancer compounds that can be used to prevent or treat breast cancer. Numerous experimental and epidemiological studies support the role of dietary phytochemicals in preventing this disease. Numerous studies have shown that apigenin has powerful antioxidant, anti-inflammatory and anticancer properties. Determining the therapeutic potential of apigenin in breast cancer by critical analysis of data from 5 countries.


2. Apigenin and prostate cancer chemoprevention


Significant differences in prostate cancer incidence in several regions of the world suggest that dietary factors may influence biological processes associated with prostate carcinogenesis. To reduce the incidence of this disease, chemoprevention through dietary intervention appears to be a practical and encouraging approach. What is the relationship between apigenin and prostate cancer? Laboratory studies in cell culture systems have shown that apigenin, a plant flavonoid abundant in fruits and vegetables, protects against a variety of human cancers. The relationship between apigenin and prostate cancer is that apigenin causes a selective response of normal cells to prostate cancer cells, inhibits cell growth, induces apoptosis, and in androgen-dependent and androgen-independent human prostate cancer cells, cells The GO-G1 phase of the cycle stalls. These new findings were designed to study the effect of oral apigenin on prostate tumorigenesis in vivo.


3. Apigenin for pancreatic cancer chemoprevention


Many chemotherapeutic agents have been used to treat pancreatic cancer without success. Apigenin Pancreatic Cancer Chemoprevention: Apigenin, a naturally occurring flavonoid that has been shown to inhibit the growth of certain cancer cell lines, apigenin inhibits cyclin B-related cdc2 activity and G2/M phase arrest To inhibit the growth of pancreatic cancer cells, it may be a valuable drug for the treatment or prevention of pancreatic cancer.

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