Chengdu Kindarco Biotech Co, Ltd.
Chengdu Kindarco Biotech Co, Ltd.

Anti-inflammatory and Antioxidant Activities of Phloretin

Phloretin is a plant polyphenol with a dihydrochalcone structure, named for its concentration in the root bark of apple trees. Due to its special structure, phloretin has a variety of biological activities, which has become a research hotspot in recent years.


1. Phloretin anti-aging and antioxidant activity


Studies have shown that the phenolic hydroxyl groups in the structure of natural flavonoids can react with free radicals to generate stable semi-quinone free radicals, thereby inhibiting the lipid peroxidation in the initial stage and terminating the free radical chain reaction. Phloretin is a flavonoid of dihydrochalcone structure with 4 phenolic hydroxyl groups, and its unique structure determines its strong antioxidant activity. In vitro experiments show that phloretin has the ability to inhibit mitochondrial lipid peroxidation and scavenge DPPH free radicals and ABTS free radicals.


Studies have shown that phloretin has strong antioxidant activity, and the antioxidant mass concentration of oil is 10.30 mg/L, which can scavenge free radicals in the skin. Phloretin not only has antioxidant effect on its own, but can also be used in combination with existing antioxidants to improve the antioxidant effect. The study found that a combination of 34.9% ferulic acid, 35.1% phloretin, and 30% water-soluble V had a synergistic antioxidant effect. At the same time, scholars used O/W microemulsion technology and embedding technology to solve the problems of poor water solubility and stability of phloretin, which provided guidance for the application of phloretin in cosmetics. It can be seen that phloretin and its inclusion complex have a good effect of scavenging free radicals, and have great application prospects in anti-aging cosmetics.


2. The anti-inflammatory activity of phloretin


In vitro studies have shown that phloretin can inhibit the production of inflammatory factors, chemokines and differentiation factors, and has a certain anti-inflammatory effect. At the same time, the study found that phloretin can inhibit the phosphorylation of single Akt and MAPK, so as to achieve anti-inflammatory effect. In vivo studies have also demonstrated that phloretin has antioxidant and anti-inflammatory effects. The anti-inflammatory effect of phloretin in vitro and in vivo indicates that it has a potential soothing effect and can be used in soothing skin care products.


In addition, modern medicine has shown that important factors related to the pathogenesis of acne and the factors that trigger inflammation are often not isolated. External application of phloretin can prevent carbohydrates from entering epidermal cells, inhibit excessive secretion of sebaceous glands, and treat exuberant acne. At the same time, entering cells can significantly reduce the activity of COX-2 promoter, inhibit the production of prostate E2, and relieve acne-type skin inflammation. 

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